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[Genetics and angiogenesis: the example of von Hippel-Lindau disease].

Bulletin du cancer - 1 Jul 2007

Richard Stéphane, Ladroue Charline, Gad Sophie, Giraud Sophie, Gardie Betty

Abstract excerpt

Von Hippel-Lindau (VHL) disease is the main cause of inherited kidney cancer and the model of tumoral angiogenesis. This rare syndrome is caused by germline mutations of the VHL tumor-suppressor gene that predispose to the development of a panel of highly vascularized tumors. Main manifestations include CNS and retinal haemangioblastomas, endolymphatic sac tumors, clear-cell renal cell carcinomas (RCC),...

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Source

Identifiers

PMID: 17846002

Genes

VHL

Provenance

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