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Article

A Vasculature-Associated Niche for Undifferentiated Spermatogonia in the Mouse Testis

6 Sept 2007

Abstract excerpt

Mammalian spermatogenesis produces numerous sperm for a long period based on a highly potent stem cell system, which relies on a special microenvironment, or niche, that has not yet been identified. In this study, using time-lapse imaging of green fluorescent protein-labeled undifferentiated spermatogonia (A(undiff)) and three-dimensional reconstitution, we revealed a biased localization of A(undiff) to the...

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PMID: 17823316
DOI: 10.1126/science.1144885

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