Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome.

Pediatric research - 1 Nov 2007

Hall Mark W, Gavrilin Mikhail A, Knatz Nina L, Duncan Michelle D, Fernandez Soledad A, Wewers Mark D

Abstract excerpt

Impairment of the ability to mount an inflammatory response is associated with death from adult critical illness. This phenomenon, characterized by reduced monocyte production of proinflammatory mediators such as tumor necrosis factor alpha (TNF-alpha), is poorly understood in children. We hypothesized that differential expression of inflammation-related genes would be seen in monocytes from children with adverse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Inflammation Mediators
Share to Interleukin-1 Receptor-Associated Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Length of Stay

Share to Multiple Organ Failure

Share to Research Design

Share to Respiration, Artificial

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 17805202
DOI: 10.1203/PDR.0b013e3181559774

Genes

TNF
IRAK1
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome.PMID 17805202Read ↗

Gene expression signatures identify pediatric patients with multiple organ dysfunction who require advanced life support in the intensive care unitSemantic proximity Read ↗

Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illnessSemantic proximity Read ↗

Role of Damage-Associated Molecular Patterns and Uncontrolled Inflammation in Pediatric Sepsis-Induced Multiple Organ Dysfunction SyndromeSemantic proximity Read ↗

Three Hypothetical Inflammation Pathobiology Phenotypes and Pediatric Sepsis-Induced Multiple Organ Failure Outcome.Semantic proximity Read ↗

Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza.Semantic proximity Read ↗

The phenotype and function of preterm infant monocytes: implications for susceptibility to infectionSemantic proximity Read ↗

Dysregulated gene expression associated with inflammatory and translation pathways in activated monocytes from children with autism spectrum disorderSemantic proximity Read ↗

Monocytes derived from humanized neonatal NOD/SCID/IL2Rγ(null) mice are phenotypically immature and exhibit functional impairments.Semantic proximity Read ↗

Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cellsSemantic proximity Read ↗

Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.