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Article

The Effect of Resveratrol on a Cell Model of Human Aging

1 Oct 2007

Abstract excerpt

The natural polyphenol resveratrol stimulates sirtuins and extends lifespan. Here resveratrol inhibited expression of replicative senescence marker INK4a in human dermal fibroblasts, and 47 of 19,000 genes from microarray experiments were differentially expressed. These included genes for growth, cell division, cell signaling, apoptosis, and transcription. Genes involved in Ras and ubiquitin pathways, Ras-GRF1,...

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PMID: 17804521
DOI: 10.1196/annals.1396.001

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