Article
Multiple endocrine neoplasia type 1 in Northern Finland; clinical features and genotype phenotype correlation.
European journal of endocrinology - 1 Sept 2007
Vierimaa O, Ebeling T M L, Kytölä S, Bloigu R, Eloranta E, Salmi J, Korpi-Hyövälti E, Niskanen L, Orvola A, Elovaara E, Gynther A, Sane T, Välimäki M, Ignatius J, Leisti J, Salmela P I
Abstract excerpt
OBJECTIVE: The existence of genotype-phenotype correlation in multiple endocrine neoplasia type 1 (MEN1) is controversial. Two founder mutations of the MEN1 gene in Northern Finland gave us an opportunity to compare clinical features among heterozygotes of different mutations. DESIGN AND METHODS: Study cohort included 82 MEN1 heterozygotes who were tested for MEN1 during the years 1982-2001. Medical records were...
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