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Article

Immunohistochemical study for the diagnosis of Alport's syndrome.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet - 1 Nov 2006

Wongtrakul Pimpong, Shayakul Chairat, Parichatikanond Paisal, Suthipinittharm Puan, Amjaroen Chalongrat, Kaewkaukul Naparat, Vongirad Arun, Ongajyooth Leena

Abstract excerpt

BACKGROUND: Alport's syndrome (AS) is the most common cause of inherited glomerular disease in Thailand. The majority of cases show X-linked inheritance, which is caused by mutations in the gene coding for the alpha5 chain of type IV collagen in the glomerular basement membrane (GBM) and epidermal basement membrane (EBM). Such mutation usually leads to a reduction in protein amount, thus, immunohistochemical...

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PMID: 17718259

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