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Article

Increased achondroplasia mutation frequency with advanced age and evidence for G1138A mosaicism in human testis biopsies.

Fertility and sterility - 1 Jun 2008

Dakouane Giudicelli Mbarka, Serazin Valerie, Le Sciellour Christelle Rouillac, Albert Martine, Selva Jacqueline, Giudicelli Yves

Abstract excerpt

OBJECTIVE: To evaluate the influence of aging on the achondroplasia mutation rate in the male germline. DESIGN: Studies in sperm and testis biopsy DNA according to donor's age. SETTING: University teaching hospital. PATIENT(S): Seventeen donors aged 30 to 65 years for sperm collection and 14 deceased donors aged 53 to 95 years for testis biopsies, all with normal stature. INTERVENTION(S): Testes were obtained...

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Identifiers

PMID: 17706214
DOI: 10.1016/j.fertnstert.2007.04.037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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