Article
Haplotype analysis of signal peptide (insertion/deletion) and XbaI polymorphisms of the APOB gene in gallbladder cancer.
Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2007
Pandey Sachchida Nand, Srivastava Anvesha, Dixit Manjusha, Choudhuri Gourdas, Mittal B
Abstract excerpt
PURPOSE: The incidence of gallbladder cancer (GBC) is usually paralleled by the prevalence of gallstone disease, and genes of cholesterol metabolism have been implicated in gallstone disease. The XbaI and insertion/deletion (ins/del) polymorphism of Apolipoprotein B (APOB) appears to influence cholesterol homoeostasis and possibly risk for gallstone disease. We examined the effect of these polymorphisms...
Topics
- Adult
- Apolipoproteins B
- Case-Control Studies
- Female
- Gallbladder Neoplasms
- Gallstones
- Gene Deletion
- Gene Expression Regulation, Neoplastic
- Gene Frequency
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Male