Article
Changes in the profile of simple mucin-type O-glycans and polypeptide GalNAc-transferases in human testis and testicular neoplasms are associated with germ cell maturation and tumour differentiation.
Virchows Archiv : an international journal of pathology - 1 Oct 2007
Rajpert-De Meyts E, Poll S N, Goukasian I, Jeanneau C, Herlihy A S, Bennett E P, Skakkebaek N E, Clausen H, Giwercman A, Mandel U
Abstract excerpt
Testicular germ cell tumours (TGCT) exhibit remarkable ability to differentiate into virtually all somatic tissue types. In this study, we investigated changes in mucin-type O-glycosylation, which have been associated with somatic cell differentiation and cancer. Expression profile of simple mucin-type O-glycans (Tn, sialyl-Tn, T), histo-blood group H and A variants and six polypeptide GalNAc-transferases (T1-4,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.