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Article

Dual effects of Tween 80 on protein stability.

International journal of pharmaceutics - 22 Jan 2008

Wang Wei, Wang Y John, Wang D Q

Abstract excerpt

In this paper, we used IL-2 mutein as a model protein and evaluated the effect of Tween 80, a non-ionic surfactant. In summary, we found that the dual effects of Tween 80 on the stability of IL-2SA, such as that shaking-induced aggregation of IL-2 mutein was significantly inhibited in the presence of Tween 80. However, this surfactant adversely affected the stability of IL-2 mutein in solution during storage in...

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Identifiers

PMID: 17692480
DOI: 10.1016/j.ijpharm.2007.06.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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