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Article

The role of the N-terminal segment of CCR5 in HIV-1 Env-mediated membrane fusion and the mechanism of virus adaptation to CCR5 lacking this segment.

Retrovirology - 8 Aug 2007

Melikyan Gregory B, Platt Emily J, Kabat David

Abstract excerpt

BACKGROUND: HIV-1 envelope glycoprotein (Env) induces membrane fusion as a result of sequential binding to CD4 and chemokine receptors (CCR5 or CXCR4). The critical determinants of CCR5 coreceptor function are the N-terminal domain (Nt) and the second extracellular loop. However, mutations in gp1...

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Share to CCR5 Receptor Antagonists
Share to HIV Envelope Protein gp120
Share to HIV Fusion Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CCR5

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Source

Open in PubMed Open full text

Identifiers

PMID: 17686153
DOI: 10.1186/1742-4690-4-55
PMCID: PMC1995219

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17686153-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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