Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children.

doi:10.1038/sj.mp.4002063

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Article

Quantitative trait locus association scan of early reading disability and ability using pooled DNA and 100K SNP microarrays in a sample of 5760 children.

Molecular psychiatry - 1 Jul 2008

Meaburn E L, Harlaar N, Craig I W, Schalkwyk L C, Plomin R

Abstract excerpt

Quantitative genetic research suggests that reading disability is the quantitative extreme of the same genetic and environmental factors responsible for normal variation in reading ability. This finding warrants a quantitative trait locus (QTL) strategy that compares low versus high extremes of the normal distribution of reading in the search for QTLs associated with variation throughout the distribution. A low...

Topics

Child
Child Development
DNA
Dyslexia
Gene Frequency
Humans
Oligonucleotide Array Sequence Analysis
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Reading

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Open in PubMed

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PMID: 17684495
DOI: 10.1038/sj.mp.4002063

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