Article
Polymorphisms in the 3' UTR in the neurocalcin delta gene affect mRNA stability, and confer susceptibility to diabetic nephropathy.
Human genetics - 1 Nov 2007
Kamiyama Masumi, Kobayashi Masaaki, Araki Shin-ichi, Iida Aritoshi, Tsunoda Tatsuhiko, Kawai Koichi, Imanishi Masahito, Nomura Makoto, Babazono Tetsuya, Iwamoto Yasuhiko, Kashiwagi Atsunori, Kaku Kohei, Kawamori Ryuzou, Ng Daniel P K, Hansen Torben, Gaede Peter, Pedersen Oluf, Nakamura Yusuke, Maeda Shiro
Abstract excerpt
Using a large-scale genotyping analysis of gene-based single nucleotide polymorphisms (SNPs) in Japanese type 2 diabetic patients, we have identified a gene encoding neurocalcin delta (NCALD) as a candidate for a susceptibility gene to diabetic nephropathy; the landmark SNP was found in the 3' UTR of NCALD (rs1131863: exon 4 +1340 A vs. G, P = 0.00004, odds ratio = 1.59, 95% CI 1.27-1.98). We also discovered two...
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