Article
Detection of a rare oligo(A) repeat tract mutation (8As-->7As) in the sequence encoding the La/SS-B autoantigen.
Analytical biochemistry - 1 Nov 2007
Semsei Imre, Maier Shannon, Workman-Azbill Jennifer, Urbán László, Moser Kathy, Zeher Margit, Bachmann Michael, Farris A Darise
Abstract excerpt
Several diseases are characterized by the presence of point mutations, which are amenable to molecular detection using a number of methods such as PCR. However, certain mutations are particularly difficult to detect due to factors such as low abundance and the presence of special (e.g., oligonucleotide repeat) sequences. The mutation 7A in the oligoA sequence of exon 7 of the gene encoding the La autoantigen is...
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