Article
Mutation analysis of the DBC2 gene in sporadic and familial breast cancer.
Acta oncologica (Stockholm, Sweden) - 1 Jan 2007
Ohadi M, Totonchi M, Maguire P, Lindblom A, Habibi R, Alavi B Afshin, Keyhani E, Najmabadi H
Abstract excerpt
The expression of the recently identified tumor suppressor gene, DBC2 (Deleted in Breast Cancer 2), is frequently extinguished in breast cancer cells or tissues. Mutation analysis of the essential promoter region, all exons and exon/intron boundaries of the DBC2 gene was performed in 100 sporadic breast cancer cases by PCR-SSCP, and DHPLC, followed by direct sequencing. An additional 17 breast cancer families,...
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