Plasma LDL cholesterol has no impact on P-glycoprotein (MDR1/ABCB1) activity in human peripheral blood mononuclear cells.

Abstract excerpt

Several studies have demonstrated that the adenosine triphosphate-binding cassette transporter P-glycoprotein (P-gp) is at least partly located in cholesterol- and sphingolipid-enriched parts of the plasma membrane called "lipid rafts" and that modification of cellular cholesterol content has an impact on the activity of P-gp in vitro and ex vivo. Cholesterol modulation in vitro does not closely reflect the in...

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