Article
Heritability of susceptibility to ionizing radiation-induced apoptosis of human lymphocyte subpopulations.
International journal of radiation oncology, biology, physics - 15 Jul 2007
Schmitz Annette, Bayer Jan, Dechamps Nathalie, Goldin Lynn, Thomas Gilles
Abstract excerpt
PURPOSE: To evaluate the heritability of intrinsic radiosensitivity, the induction of apoptosis in lymphocyte subpopulations was determined on samples from related individuals belonging to large kindred families. METHODS AND MATERIALS: Quiescent lymphocytes from 334 healthy individuals were gamma-irradiated in vitro. Apoptosis was determined 18 h after irradiation by eight-color flow cytometry. Radiosensitivity...
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