Article
Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in BRCA1 and BRCA2.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2025
Phillips Kelly-Anne, Kotsopoulos Joanne, Domchek Susan M, Terry Mary Beth, Chamberlain James A, Bassett Julie K, Aeilts Amber M, Andrulis Irene L, Buys Saundra S, Cui Wanda, Daly Mary B, Eisen Andrea F, Foulkes William D, Friedlander Michael L, Gronwald Jacek, Hopper John L, John Esther M, Karlan Beth Y, Kim Raymond H, Kurian Allison W, Lubinski Jan, Metcalfe Kelly, Nathanson Katherine L, Singer Christian F, Southey Melissa C, Symecko Heather, Tung Nadine, Narod Steven A, Milne Roger L
Abstract excerpt
PURPOSE: It is uncertain whether, and to what extent, hormonal contraceptives increase breast cancer (BC) risk for germline BRCA1 or BRCA2 mutation carriers. METHODS: Using pooled observational data from four prospective cohort studies, associations between hormonal contraceptive use and BC risk for unaffected female BRCA1 and BRCA2 mutation carriers were assessed using Cox regression. RESULTS: Of 3,882 BRCA1 and...
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