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Article

A fungal gene for antibiotic resistance on a dispensable ("B") chromosome.

Science (New York, N.Y.) - 20 Dec 1991

Miao V P, Covert S F, VanEtten H D

Abstract excerpt

A family of cytochrome P-450 (Pda) genes in the pathogenic fungus Nectria haematococca is responsible for the detoxification of the phytoalexin pisatin, an antimicrobial compound produced by garden pea (Pisum sativum L.). The Pda6 gene was mapped by electrophoretic karyotype analysis to a small meiotically unstable chromosome that is dispensable for normal growth. Such traits are typical of B chromosomes. The...

Topics

Benzopyrans
Chromosome Mapping
Chromosomes, Fungal
Crosses, Genetic
Cytochrome P-450 Enzyme System
Drug Resistance, Microbial
Fabaceae
Genes, Fungal
Hypocreales
Karyotyping
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plants, Medicinal

Pterocarpans

Source

Identifiers

PMID: 1763326
DOI: 10.1126/science.1763326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1763326-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A fungal gene for antibiotic resistance on a dispensable ("B") chromosome.PMID 1763326Read ↗

Identification and chromosomal locations of a family of cytochrome P-450 genes for pisatin detoxification in the fungus Nectria haematococca.Semantic proximity Read ↗

Identification of new pisatin demethylase genes (PDA5 and PDA7) in Nectria haematococca and non-Mendelian segregation of pisatin demethylating ability and virulence on pea due to loss of chromosomal elements.Semantic proximity Read ↗

An ABC transporter and a cytochrome P450 of Nectria haematococca MPVI are virulence factors on pea and are the major tolerance mechanisms to the phytoalexin pisatin.Semantic proximity Read ↗

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