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Article

Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women.

Breast cancer research and treatment - 1 May 2008

Sakoda Lori C, Blackston Christie R, Xue Kan, Doherty Jennifer A, Ray Roberta M, Lin Ming Gang, Stalsberg Helge, Gao Dao Li, Feng Ziding, Thomas David B, Chen Chu

Abstract excerpt

Enzymes encoded by the glutathione S-tranferase mu 1 (GSTM1) and pi 1 (GSTP1) genes, which are expressed in breast tissue, catalyze the detoxification of endogenous and exogenous electrophiles. Reduced enzyme activity, due to carriage of the GSTM1 deletion or the GSTP1 Ile105Val Val allele, may therefore affect susceptibility to breast cancer and related conditions. In a case-control study of Chinese women, we...

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Identifiers

PMID: 17624589
DOI: 10.1007/s10549-007-9633-5
PMCID: PMC2741390

Genes

GSTM1
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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