Article
[Analysis of expression of parental alleles Xist and Gla in interspecific embryonic hybrid cells during induced in vitro inactivation of X-chromosomes].
Ontogenez - 1 Jan 2000
Puzakov M V, Battulin N R, Temirova S A, Matveeva N M, Serdiukova N A, Grafodatskiĭ A S, Serov O L
Abstract excerpt
The results of in situ hybridization with labeled species specific and X-chromosome-specific probes suggest that hybrid cells obtained by fusion of Mus musculus embryonic stem cells (genotype XY) and splenocytes of M. caroli females contain two parental X-chromosomes. In five clones of hybrid cells, differentiation was induced in embryoid bodies in vitro, which was accompanied by inactivation of one of...
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