Article
In CEM cells the autosomal deafness gene dfna5 is regulated by glucocorticoids and forskolin.
The Journal of steroid biochemistry and molecular biology - 1 Oct 2007
Webb M S, Miller A L, Thompson E Brad
Abstract excerpt
Certain mutations of the dfna5 gene result in a form of autosomal deafness that holds special interest because its phenotype resembles the hearing loss often seen during aging. Little is known of the function or regulation of dfna5 or its encoded protein. However dfna5 has recently been shown to be induced by p53. It also is epigenetically repressed in gastric cancer. We have discovered that dfna5 can be induced...
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