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Article

A mitochondrial bottleneck hypothesis of Alzheimer's disease.

Molecular medicine today - 1 Aug 1995

Davis J N, Hunnicutt E J, Chisholm J C

Abstract excerpt

Alzheimer's disease, in its early onset familial form, is known to be a heterogeneous disorder. This suggests that the different degenerative mechanisms, initiated by different genetic causes and ending in the shared phenotype of the disease, should intersect at some point in the degenerative cascade to form a 'bottleneck' from which the pathological features that are common to each of the genetic forms emerge. A...

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PMID: 17607886
DOI: 10.1016/s1357-4310(95)91532-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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