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Article

Population quantile-quantile plots for monitoring assay performance in newborn screening.

Journal of inherited metabolic disease - 1 Aug 2007

Pollitt R J, Matthews A J

Abstract excerpt

Immunoreactive trypsinogen (IRT) used in screening for cystic fibrosis is heterogeneous, poorly characterized, and displays marked matrix effects when incorporated into blood spots, making long-term control of assay calibration difficult. The cut-off required to select a fixed proportion of samples (0.5% for the UK protocol) for second-tier mutation analysis varies over time, partly owing to slight differences in...

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PMID: 17603757
DOI: 10.1007/s10545-007-0573-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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