Article
[The biology of nasopharyngeal carcinoma in 2001: update and perspective].
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique - 1 Nov 2001
Busson P, Ardila-Osorio H, Pioche-Durieu C, Vicat J M
Abstract excerpt
The phenotype of malignant epithelial cells in nasopharyngeal carcinomas (NPC) results from latent infection by the Epstein-Barr virus (EBV) combined to cell gene alterations, especially those affecting the p16/Ink 4 gene. At the site of the primary tumor, NPC are strongly infiltrated by non-malignant EBV-negative T-lymphocytes. There are experimental clues suggesting that these lymphocytes are involved in tumor...
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