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Targeted inhibition of HBV gene expression by single-chain antibody mediated small interfering RNA delivery

27 Jun 2007

Abstract excerpt

UNLABELLED: RNA interference is highly effective at inhibiting HBV gene expression and replication. However, before small interfering RNA (siRNA) can be used in the clinic, it is essential to develop a system to target their delivery. Antibody-mediated delivery is a novel approach for targeting siRNA to appropriate cells. In this report, we asked whether this siRNA delivery strategy would be effective against...

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PMID: 17596868
DOI: 10.1002/hep.21663

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