Article
Constructing a meaningful evolutionary average at the phylogenetic center of mass.
BMC bioinformatics - 26 Jun 2007
Stone Eric A, Sidow Arend
Abstract excerpt
BACKGROUND: As a consequence of the evolutionary process, data collected from related species tend to be similar. This similarity by descent can obscure subtler signals in the data such as the evidence of constraint on variation due to shared selective pressures. In comparative sequence analysis, for example, sequence similarity is often used to illuminate important regions of the genome, but if the comparison is...
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