Article
Adrenergic receptor genotype but not perioperative bisoprolol therapy may determine cardiovascular outcome in at-risk patients undergoing surgery with spinal block: the Swiss Beta Blocker in Spinal Anesthesia (BBSA) study: a double-blinded, placebo-controlled, multicenter trial with 1-year follow-up.
Anesthesiology - 1 Jul 2007
Zaugg Michael, Bestmann Lukas, Wacker Johannes, Lucchinetti Eliana, Boltres Anita, Schulz Christian, Hersberger Martin, Kälin Gabriela, Furrer Lukas, Hofer Christoph, Blumenthal Stephan, Müller Annabelle, Zollinger Andreas, Spahn Donat R, Borgeat Alain
Abstract excerpt
BACKGROUND: Neuraxial blockade is used as primary anesthetic technique in one third of surgical procedures. The authors tested whether bisoprolol would protect patients at risk for cardiovascular complications undergoing surgery with spinal block. METHODS: The authors performed a double-blinded, placebo-controlled, multicenter trial to compare the effect of bisoprolol with that of placebo on 1-yr composite...
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