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Aberrations in chromosomes associated with lymphoma and therapy‐related leukemia in benzene‐exposed workers

21 Jun 2007

Abstract excerpt

Epidemiological studies show that benzene exposure is associated with an increased incidence of leukemia and perhaps lymphoma. Chromosomal rearrangements are common in these hematopoietic diseases. Translocation t(14;18), the long-arm deletion of chromosome 6 [del(6q)], and trisomy 12 are frequently observed in lymphoma patients. Rearrangements of the MLL gene located on chromosome 11q23, such as t(4;11) and...

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PMID: 17584886
DOI: 10.1002/em.20306

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