Article
Carcinogenic susceptibility of rasH2 mice to troglitazone.
Archives of toxicology - 1 Dec 2007
Jin Meilan, Takahashi Miwa, Moto Mitsuyoshi, Muguruma Masako, Ito Kazumi, Watanabe Kyoko, Kenmochi Yusuke, Kono Taichi, Hasumi Keiji, Mitsumori Kunitoshi
Abstract excerpt
To evaluate the carcinogenicity of troglitazone in rasH2 mice, 7-week-old male and female rasH2 mice were fed a diet containing 0, 3,000 or 6,000 ppm troglitazone for 26 weeks. An increased tendency in the incidence of vascular tumors was observed in females of the 6,000 ppm group. The preliminar...
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