Examining emergence of functional gene clustering in a simulated evolution.

Abstract excerpt

Recent research suggests that rather than being random, gene order may be coupled with gene functionality. These findings may be explained by mechanisms that require physical proximity such as co-expression and co-regulation. Alternatively, they may be due to evolutionary-dynamics forces, as expressed in genetic drift or linkage disequilibrium. This paper proposes a biologically plausible model for evolutionary...

Topics

• Algorithms
• Computer Simulation
• Epistasis, Genetic
• Evolution, Molecular
• Gene Order
• Gene Regulatory Networks
• Genetic Drift
• Genetic Linkage
• Genetics, Population
• Haploidy
• Models, Genetic
• Multigene Family
• Mutation
• Recombination, Genetic
• Selection, Genetic
• Stochastic Processes