Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FGF2 effects in periosteal fibroblasts bearing the FGFR2 receptor Pro253 Arg mutation.

Cytokine - 1 Apr 2007

Lilli Cinzia, Bellucci Catia, Baroni Tiziano, Aisa Cristina, Carinci Paolo, Scapoli Luca, Carinci Francesco, Pezzetti Furio, Lumare Eleonora, Stabellini Giordano, Bodo Maria

Abstract excerpt

AIM: A growing number of mutations mapped in the receptor gene for fibroblast growth factor have been implicated in several cranial development disorders including the Apert and Crouzon syndromes. The present paper investigated cellular mechanisms underlying Apert phenotype, by analyzing the effe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acrocephalosyndactylia
Share to Craniofacial Dysostosis
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibronectins

Share to Glycoside Hydrolases

Share to Matrix Metalloproteinase 1

Share to Proteoglycans

Share to Receptor, Fibroblast Growth Factor, Type 2

Source

Identifiers

PMID: 17537644
DOI: 10.1016/j.cyto.2007.04.007

Genes

FGF2
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17537644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FGF2 effects in periosteal fibroblasts bearing the FGFR2 receptor Pro253 Arg mutation.PMID 17537644Read ↗

P253R fibroblast growth factor receptor-2 mutation induces RUNX2 transcript variants and calvarial osteoblast differentiation.Semantic proximity Read ↗

Novel molecular pathways elicited by mutant FGFR2 may account for brain abnormalities in Apert syndrome.Semantic proximity Read ↗

The pleiotropic effects of fibroblast growth factor receptors in mammalian development.Semantic proximity Read ↗

Apert p.Ser252Trp mutation in FGFR2 alters osteogenic potential and gene expression of cranial periosteal cells.Semantic proximity Read ↗

[Molecular genetics of congenital skeletal dysplasias related to mutations of fibroblast growth factor receptors].Semantic proximity Read ↗

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities.Semantic proximity Read ↗

Role of the extracellular matrix and growth factors in skull morphogenesis and in the pathogenesis of craniosynostosis.Semantic proximity Read ↗

Negative autoregulation of fibroblast growth factor receptor 2 expression characterizing cranial development in cases of Apert (P253R mutation) and Pfeiffer (C278F mutation) syndromes and suggesting a basis for differences in their cranial phenotypes.Semantic proximity Read ↗

Cell Type-Dependent Nonspecific Fibroblast Growth Factor Signaling in Apert Syndrome.Semantic proximity Read ↗

Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome.Semantic proximity Read ↗

A Ser252Trp mutation in fibroblast growth factor receptor 2 (FGFR2) mimicking human Apert syndrome reveals an essential role for FGF signaling in the regulation of endochondral bone formation.Semantic proximity Read ↗

Understanding the molecular basis of Apert syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.