Article
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
European journal of endocrinology - 1 Jun 2007
Nielsen Lotte B, Ploug Kenneth B, Swift Peter, Ørskov Cathrine, Jansen-Olesen Inger, Chiarelli Francesco, Holst Jens J, Hougaard Philip, Pörksen Sven, Holl Reinhard, de Beaufort Carine, Gammeltoft Steen, Rorsman Patrik, Mortensen Henrik B, Hansen Lars
Abstract excerpt
OBJECTIVE: The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucos...
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