Article
Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily.
FEBS letters - 12 Jun 2007
Virdee Kanwar, Yoshida Hirotaka, Peak-Chew Sew, Goedert Michel
Abstract excerpt
Intraneuronal inclusions made of hyperphosphorylated microtubule-associated protein tau are a defining neuropathological characteristic of Alzheimer's disease, and of several other neurodegenerative disorders. Many phosphorylation sites in tau are S/TP sites that flank the microtubule-binding repeats. Others are KXGS motifs in the repeats. One site upstream of the repeats lies in a consensus sequence for AGC...
Topics
- Amino Acid Sequence
- Binding Sites
- Glycogen Synthase Kinase 3
- Glycogen Synthase Kinase 3 beta
- Humans
- Immediate-Early Proteins
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Phosphorylation
- Protein Kinases