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Article

A minimal and self-consistent in silico cell model based on macromolecular interactions.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Oct 2007

Flamm Christoph, Endler Lukas, Müller Stefan, Widder Stefanie, Schuster Peter

Abstract excerpt

A self-consistent minimal cell model with a physically motivated schema for molecular interaction is introduced and described. The genetic and metabolic reaction network of the cell is modelled by multidimensional nonlinear ordinary differential equations, which are derived from biochemical kinetics. The strategy behind this modelling approach is to keep the model sufficiently simple in order to be able to...

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PMID: 17510017
DOI: 10.1098/rstb.2007.2075
PMCID: PMC2442397

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