Article
Rapid detection of the UGT1A1 single nucleotide polymorphism G211A using real-time PCR with Taqman minor groove binder probes.
Journal of clinical laboratory analysis - 1 Jan 2007
Wong Fei-Liang, Wang May-Kay, Boo Nem-Yun, Hamidah N H, Ainoon B Othaman
Abstract excerpt
The UGT1A1 Taqman MGB probe single nucleotide polymorphism (SNP) genotyping assay was developed to detect nucleotide 211 of the UDP-glucoronocyltransferase 1A1 (UGT1A1) gene. Defects in this enzyme interfere with process of conjugation of bilirubin and cause unconjugated hyperbilirubinemia. Variation at nucleotide 211 in the coding region of the UGT1A1 gene has been shown to be prevalent in Japanese and Chinese....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
