Thuggacins, Macrolide Antibiotics Active against <i>Mycobacterium tuberculosis</i>: Isolation from Myxobacteria, Structure Elucidation, Conformation Analysis and Biosynthesis

Abstract excerpt

Two novel antibiotics, thuggacin A (1) and B (2), were isolated from the myxobacterium Sorangium cellulosum. 1 and 2 are unique thiazole-containing macrolides with side chains on both sides of the lactone group. Upon standing in solution, thuggacin A (1) rearranges by acyl migration of the lactone group to give a mixture with thuggacins B (2) and C (3). NOEs and vicinal coupling constants within the lactone ring...

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