Is there evidence of a therapy-related increase in germ cell mutation among childhood cancer survivors?

Abstract excerpt

Few studies have examined human population data for evidence of an association between environmental mutagens and genetic disease. Our objective was to determine whether study of pregnancies and offspring of childhood cancer survivors would show evidence that therapy potentially mutagenic to germ cells is associated with increased risk of miscarriage, serious congenital abnormalities, or altered sex ratio. We...

Topics

• Antineoplastic Agents
• Congenital Abnormalities
• Female
• Germ Cells
• Humans
• Male
• Mutation
• Neoplasms
• Pilot Projects
• Pregnancy
• Pregnancy Outcome
• Radiotherapy