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Article

Genetic and teratogenic effects of cancer treatments on gametes and embryos

1 Jul 2001

Abstract excerpt

Male and female germ cells vary in their sensitivity to the mutagenic effects of chemotherapy and radiotherapy, depending on their stage of maturation and the agent used. Although sperm DNA damage exists following treatment, no increase in genetic defects or congenital malformations was detected among children conceived to parents who have previously undergone chemotherapy or radiotherapy. The use of assisted...

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Identifiers

PMID: 11476352
DOI: 10.1093/humupd/7.4.394

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Source receipt: pubmed, retrieved 7 Sept 2026.

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