Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic Cyclophosphamide Exposure Alters the Profile of Rat Sperm Nuclear Matrix Proteins1

3 May 2007

Abstract excerpt

Chronic exposure of male rats to the alkylating agent cyclophosphamide, a well-known male-mediated developmental toxicant, alters gene expression in male germ cells as well as in early preimplantation embryos sired by cyclophosphamide-exposed males. Sperm DNA is organized by the nuclear matrix into loop-domains in a sequence-specific manner. In somatic cells, loop-domain organization is involved in gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Effects and risks of endocrine disrupting chemicals
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17475930
DOI: 10.1095/biolreprod.107.060244

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic Cyclophosphamide Exposure Alters the Profile of Rat Sperm Nuclear Matrix Proteins1PMID 17475930Read ↗

Transcriptomic and proteomic features of sperm DNA damage mouse model induced by benzo(a)pyreneSemantic proximity Read ↗

The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agentsSemantic proximity Read ↗

Exposure to Bleomycin, Etoposide, and Cis-Platinum Alters Rat Sperm Chromatin Integrity and Sperm Head Protein Profile1Semantic proximity Read ↗

The Effects of Chemotherapeutic Agents, Bleomycin, Etoposide, and Cisplatin, on Chromatin Remodeling in Male Rat Germ Cells1Semantic proximity Read ↗

Function of the Sperm Nuclear MatrixSemantic proximity Read ↗

Defining the Mechanisms by Which the Reactive Oxygen Species By-Product, 4-Hydroxynonenal, Affects Human Sperm Cell Function1Semantic proximity Read ↗

Toxicoepigenetic Alteration of the Kidney Injury Molecule 1 Gene in Gentamicin-Exposed Rat KidneySemantic proximity Read ↗

miRNA regulation of cytotoxic effects in mouse Sertoli cells exposed to nonylphenolSemantic proximity Read ↗

Nuclear structure and the three‐dimensional organization of DNASemantic proximity Read ↗

Sperm mRNA Transcripts Are Indicators of Sub-Chronic Low Dose Testicular Injury in the Fischer 344 RatSemantic proximity Read ↗

RNA sequencing analysis of embryos exposed to nanoplastics: effects on developmental and transcriptomic alterationSemantic proximity Read ↗

Analysis of Protein Thiol Changes Occurring During Rat Sperm Epididymal Maturation1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.