Article
Following evolution's lead to a single residue switch for diterpene synthase product outcome.
Proceedings of the National Academy of Sciences of the United States of America - 1 May 2007
Xu Meimei, Wilderman P Ross, Peters Reuben J
Abstract excerpt
There have been few insights into the biochemical origins of natural product biosynthesis from primary metabolism. Of particular interest are terpene synthases, which often mediate the committed step in particular biosynthetic pathways so that alteration of their product outcome is a key step in...
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