Article
Identification of the Fanconi anemia complementation group I gene, FANCI.
Cellular oncology : the official journal of the International Society for Cellular Oncology - 1 Jan 2007
Dorsman Josephine C, Levitus Marieke, Rockx Davy, Rooimans Martin A, Oostra Anneke B, Haitjema Anneke, Bakker Sietske T, Steltenpool Jûrgen, Schuler Dezsö, Mohan Sheila, Schindler Detlev, Arwert Fré, Pals Gerard, Mathew Christopher G, Waisfisz Quinten, de Winter Johan P, Joenje Hans
Abstract excerpt
To identify the gene underlying Fanconi anemia (FA) complementation group I we studied informative FA-I families by a genome-wide linkage analysis, which resulted in 4 candidate regions together encompassing 351 genes. Candidates were selected via bioinformatics and data mining on the basis of their resemblance to other FA genes/proteins acting in the FA pathway, such as: degree of evolutionary conservation,...
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