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Article

Sulfonylurea-responsive diabetes in childhood.

The Journal of pediatrics - 1 May 2007

Landau Zohar, Wainstein Julio, Hanukoglu Aaron, Tuval Myriam, Lavie Judith, Glaser Benjamin

Abstract excerpt

We describe a family in which 3/6 siblings had transient, relapsing neonatal diabetes. The father and another sibling had diabetes diagnosed at 20 and 9 years old, respectively. All affected individuals carried the same KCNJ11 gene mutation. In all, sulfonylurea treatment permitted cessation of insulin treatment, with improved glycemic control.

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hypoglycemic Agents

Share to Infant, Newborn

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Share to Potassium Channels, Inwardly Rectifying

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Source

Identifiers

PMID: 17452235
DOI: 10.1016/j.jpeds.2007.03.004

Genes

KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Sulfonylurea-responsive diabetes in childhood.PMID 17452235Read ↗

Permanent neonatal diabetes by a new mutation in KCNJ11: unsuccessful switch to sulfonylurea.Semantic proximity Read ↗

Sulfonylurea-responsive neonatal diabetes mellitus diagnosed through molecular genetics in two children and in one adult after a long period of insulin treatment.Semantic proximity Read ↗

Sulfonylurea vs insulin therapy in individuals with sulfonylurea-sensitive permanent neonatal diabetes mellitus, attributable to a KCNJ11 mutation, and poor glycaemic control.Semantic proximity Read ↗

Comparison of diabetes phenotype in children and their mothers with permanent neonatal diabetes mellitus carrying the same KCNJ11 variants.Semantic proximity Read ↗

Effectiveness and safety of long-term treatment with sulfonylureas in patients with neonatal diabetes due to KCNJ11 mutations: an international cohort study.Semantic proximity Read ↗

Detection of KCNJ11 gene mutations in a family with neonatal diabetes mellitus: implications for therapeutic management of family members with long-standing disease.Semantic proximity Read ↗

Mother and daughter carrying the same KCNJ11 mutation but with a different response to switching from insulin to sulfonylurea.Semantic proximity Read ↗

Successful Transition From Insulin to Sulfonylurea Therapy in a Patient With Monogenic Neonatal Diabetes Owing to a KCNJ11 P333L Mutation. Diabetes Care 2013;36:e201Semantic proximity Read ↗

Familial permanent neonatal diabetes with KCNJ11 mutation and the response to glyburide therapy--a three-year follow-up.Semantic proximity Read ↗

Relapsing diabetes can result from moderately activating mutations in KCNJ11.Semantic proximity Read ↗

Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.Semantic proximity Read ↗

Clinical Characteristics, Molecular Features, and Long-Term Follow-Up of 15 Patients with Neonatal Diabetes: A Single-Centre Experience.Semantic proximity Read ↗

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