Article
A copper-activated two-component system interacts with zinc and imipenem resistance in Pseudomonas aeruginosa.
Journal of bacteriology - 1 Jul 2007
Caille Olivier, Rossier Claude, Perron Karl
Abstract excerpt
The effects of copper (Cu) on trace metal and antibiotic resistance of Pseudomonas aeruginosa have been investigated. Cu treatments induced resistance not only to this metal but also, surprisingly, to zinc (Zn). Quantitative reverse transcription-PCR (qRT-PCR) revealed that after Cu treatment the transcription of the czcRS two-component system (TCS) operon was enhanced as well as that of the czcCBA operon...
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