Article
Gene-environment interactions in parkinsonism and Parkinson's disease: the Geoparkinson study.
Occupational and environmental medicine - 1 Oct 2007
Dick F D, De Palma G, Ahmadi A, Osborne A, Scott N W, Prescott G J, Bennett J, Semple S, Dick S, Mozzoni P, Haites N, Wettinger S Bezzina, Mutti A, Otelea M, Seaton A, Soderkvist P, Felice A
Abstract excerpt
OBJECTIVES: To investigate associations of Parkinson's disease (PD) and parkinsonian syndromes with polymorphic genes that influence metabolism of either foreign chemical substances or dopamine and to seek evidence of gene-environment interaction effects that modify risk. METHODS: A case-control study of 959 prevalent cases of parkinsonism (767 with PD) and 1989 controls across five European centres. Occupational...
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