Article
Expression of Tie-2 and other receptors for endothelial growth factors in acute myeloid leukemias is associated with monocytic features of leukemic blasts.
Stem cells (Dayton, Ohio) - 1 Aug 2007
Riccioni Roberta, Diverio Daniela, Mariani Gualtiero, Buffolino Sonia, Riti Viviana, Saulle Ernestina, Petrucci Eleonora, Cedrone Michele, Lo-Coco Francesco, Foà Robin, Peschle Cesare, Testa Ugo
Abstract excerpt
We investigated the expression of Tie-2 in primary blasts from 111 patients with acute myeloid leukemia (AML) to evaluate a possible linkage between the expression of this receptor and the immunophenotypic and biologic properties of leukemic blasts. Tie-2 was expressed at moderate and high levels in 39 and 23 of 111 AMLs, respectively. The analysis of the immunophenotype clearly showed that Tie-2 expression in...
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