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[Functional expression of congenital long QT syndrome related HERG mutation A561V in vitro].

Zhonghua xin xue guan bing za zhi - 1 Feb 2007

Li Yu, Cui Chang-cong, Zhao Yong-hui, Xue Xiao-lin, Zhang Ai-feng, Lian Jiang-fang, Huang Chen

Abstract excerpt

OBJECTIVE: To investigate the functional expression of HERG mutation A561V detected in a Chinese congenital long QT syndrome family. METHODS: The mutation gene A561V was cloned into eukaryotic expressive vector pcDNA3 by quick site-directed mutagenesis PCR and restriction enzymes. The wild-type HERG, heterozygous type HERG and HERG mutation A561V were respectively cotransfected with pRK5-GFP into HEK293 cells by...

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PMID: 17445409

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