Article
Anorexia nervosa, perfectionism, and dopamine D4 receptor (DRD4).
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Sept 2007
Bachner-Melman Rachel, Lerer Elad, Zohar Ada H, Kremer Ilana, Elizur Yoel, Nemanov Lubov, Golan Moria, Blank Shulamit, Gritsenko Inga, Ebstein Richard P
Abstract excerpt
The dopamine D4 receptor (DRD4), a well-characterized, polymorphic gene, is an attractive candidate for contributing risk to disordered eating and anorexia nervosa (AN). We tested association using UNPHASED for 5 DRD4 polymorphic loci, 3 promoter region SNPs (C-521T, C-616G, A-809G), the 120 bp promoter region tandem duplication and the exon III repeat, in 202 AN trios and 418 control families. Since...
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