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Article

Sequence determinants of E2-E6AP binding affinity and specificity.

Journal of molecular biology - 1 Jun 2007

Eletr Ziad M, Kuhlman Brian

Abstract excerpt

The conjugation of ubiquitin to substrates requires a series of enzymatic reactions consisting of an activating enzyme (E1), conjugating enzymes (E2) and ligases (E3). Tagging the appropriate substrate with ubiquitin is achieved by specific E2-E3 and E3-substrate interactions. E6AP, a member of the HECT family of E3s, has been previously shown to bind and function with the E2s UbcH7 and UbcH8. To decipher the...

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Share to Protein Structure, Tertiary
Share to Saccharomyces cerevisiae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Sequence Alignment

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Source

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Identifiers

PMID: 17433363
DOI: 10.1016/j.jmb.2007.03.026
PMCID: PMC1945100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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