Article
The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.
Human genetics - 1 Jun 2007
Zogopoulos George, Rothenmund Heidi, Eppel Ayelet, Ash Colleen, Akbari Mohammad Reza, Hedley David, Narod Steven A, Gallinger Steven
Abstract excerpt
The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant...
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